Looking for Online Courses - CLICK HERE

Helpline no. 0129-4259000

Helpline no. 0129-4259000


Applications of Stem Cells

Stem cells have a capacity for self-renewal and capability of proliferation and differentiation to various cell lineages. They can be classified into embryonic stem cells (ESC) and non-embryonic stem cells (non-ESC). Mesenchymal stem cells (MSC) show great promise in several animal studies and clinical trials. ESCs have a great potential but their use is still limited due to ethical and scientific considerations. The use of amniotic fluid derived cells, umbilical cord cells, fat and skintissues and monocytes might be an adequate ‘ethically pure’ alternative in future.

Stem cells can improve healthcare by using and augmenting the body’s own regenerative potential. There is much to be investigated about the specific characteristics of stem cells and about the efficacy and safety of the new drugs based on this type of cells, both embryonic as adult stem cells, for several therapeutic indications (cardiovascular and ischemic diseases, diabetes, hematopoietic diseases, liver diseases). Along with recent progress in transference of nuclei from human somatic cells, as well as iPSC technology, has allowed availability of lineages of all three germ layers genetically identical to those of the donor patient, which permits safe transplantation of organ-tissue-specific adult stem cells with no immune rejection. The main objective is the need for expansion of stem cell characteristics to maximize stem cell efficacy (i.e. the proper selection of a stem cell) and the efficacy(maximum effect) and safety of stem cell derived drugs. Other considerations to take into account in cell therapy will be the suitability of infrastructure and technical staff, biomaterials, production costs, bio-banks, bio-security, and the biotechnological industry. The general objectives in the area of stem cell research in the next few years, are related to identification of therapeutic targets and potential therapeutic tests, studies of cell differentiation and physiological mechanisms, culture conditions of pluri potent stem cells and efficacy and safety tests for stem cell-based drugs or procedures to be performed in both animal and human models in the corresponding clinical trials. A regulatory framework will be required to ensure patient accessibility to products and governmental assistance for their regulation and control. Bioethical aspects will be required related to the scientific and therapeutic relevance and cost of cryopreservation over time, but specially with respect to embryos which may ultimately be used for scientific uses of research as source of embryonic stem cells, in which case the bioethical conflict may be further aggravated.

Skip to content